Levistilide A Ameliorates NLRP3 Expression Involving the Syk-p38/JNK Pathway and Peripheral Obliterans in Rats

<div>LA suppressed NLRP3 gene and downstream related protein expression. HUVECs were treated with 50 <i>μ</i>M of LA for 1 h, and then LPS was stimulated for 24 h. The NLRP3 mRNA level (a) was analyzed using qRT-PCR. LA and p38/JNK inhibitors (SB203580 and SP600125) were treated with HUVECs for 60 min before LPS stimulation for 24 h. NLRP3-associated proteins IL-1<i>β</i> and IL-18 were detected using immunoblotting (b)(c). 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Mediators of Inflammation

fig3

Figure 3

Figure 3: Levistilide A Ameliorates NLRP3 Expression Involving the Syk-p38/JNK Pathway and Peripheral Obliterans in Rats 