Plasma Asprosin Levels Are Associated with Glucose Metabolism, Lipid, and Sex Hormone Profiles in Females with Metabolic-Related Diseases
Table 2
Metabolic characteristics of T2DM and PCOS females in normal-weight and overweight subgroups categorized by BMI.
T2DM normal-weight
T2DM overweight/obese
PCOS normal-weight
PCOS overweight/obese
Age (years)
47.48 ± 4.86
46.72 ± 5.01
0.589
20.33 ± 5.18
23.66 ± 5.65
0.087
BMI (kg/m2)
21.90 ± 1.64
27.00 ± 2.46
<0.001
22.24 ± 1.44
28.97 ± 3.37
<0.001
WHR
0.83 ± 0.10
0.93 ± 0.07
<0.001
0.86 ± 0.07
0.91 ± 0.10
0.064
SBP (mmHg)
122.76 ± 12.53
126.56 ± 10.03
0.227
115.27 ± 11.68
119.21 ± 10.60
0.316
DBP (mmHg)
76.48 ± 9.33
77.34 ± 8.54
0.729
71.73 ± 6.05
77.79 ± 8.66
0.040
FBG (mmol/L)
7.10 ± 1.99
7.84 ± 3.46
0.385
4.27 ± 0.62
4.93 ± 2.60
0.391
FINS (mU/mL)
9.08 ± 5.15
11.29 ± 6.88
0.216
11.63 ± 3.36
15.85 ± 6.37
0.037
HbA1c (%)
8.42 ± 2.72
9.02 ± 2.23
0.405
5.20 ± 0.25
6.41 ± 1.87
0.003
HOMA-IR
2.15 (1.26–3.17)
3.14 (2.07–5.28)
0.106
1.61 (1.02–2.01)
3.19 (2.63–4.23)
0.007
HOMA-β
44.05 (21.23–98.67)
56.66 (30.75–87.21)
0.611
259.20 (181.13–368.19)
158.44 (133.33–474.03)
0.915
OGTT-30 min insulin (mU/mL)
23.80 (11.05–30.05)
17.90 (13.3–28.1)
0.960
40.55 (35.43–77.10)
62.10 (36.40–98.00)
0.231
OGTT-60 min insulin (mU/mL)
21.50 (10.35–53.70)
28.00 (20.90–55.35)
0.490
43.90 (40.75–52.00)
91.40 (60.70–138.00)
0.004
OGTT-120 min insulin (mU/mL)
26.00 (14.15–48.30)
30.60 (18.45–59.05)
0.375
34.30 (24.28–64.35)
84.60 (57.60–179.10)
0.034
OGTT-180 min insulin (mU/mL)
13.50 (10.20–24.10)
22.90 (13.25–35.40)
0.043
14.05 (5.98–27.30)
55.70 (34.30–88.90)
0.601
OGTT-IAUC
3886.50 (2090.25–7894.50)
4779.00 (3212.25–7833.00)
0.397
6000.75 (5749.13–8155.88)
15915.00 (9030.00–21195.00)
0.041
TG (mmol/L)
1.83 ± 1.13
2.05 ± 1.24
0.513
1.43 ± 0.74
1.69 ± 0.91
0.444
TC (mmol/L)
4.66 ± 0.83
4.79 ± 1.02
0.632
3.86 ± 0.64
4.67 ± 1.09
0.045
LDL-C (mmol/L)
3.08 ± 0.66
3.25 ± 0.86
0.464
2.44 ± 0.60
3.01 ± 0.81
0.065
HDL-C (mmol/L)
1.25 ± 0.33
1.12 ± 0.22
0.111
1.14 ± 0.14
1.23 ± 0.44
0.535
AST (IU/L)
19.68 ± 10.85
23.50 ± 15.66
0.359
17.42 ± 4.78
24.98 ± 12.71
0.094
ALT (IU/L)
23.18 ± 13.93
27.00 ± 20.49
0.483
14.15 ± 7.08
28.25 ± 18.74
0.002
γ-GGT (IU/L)
16.10 (13.70–32.70)
21.70 (15.50–34.10)
0.062
17.25 (12.03–29.98)
29.50 (23.90–56.70)
0.018
WBC (109/L)
5.67 ± 1.42
6.36 ± 2.10
0.182
6.43 ± 1.93
7.25 ± 1.53
0.144
CRP (mg/L)
5.22 ± 0.60
5.53 ± 1.79
0.155
4.71 ± 2.16
4.10 ± 1.90
0.423
Notes: Data are presented as deviation for normally distributed variables and median (interquartile range) for nonnormally distributed variables. values are from unpaired test or Mann-Whitney test. –21 normal-weight T2DM subjects, –32 overweight/obese T2DM subjects, –12 normal-weight PCOS subjects, –29 overweight/obese PCOS subjects. OGTT: oral glucose tolerance test; IAUC: insulin area under the curve.
