Plasma Asprosin Levels Are Associated with Glucose Metabolism, Lipid, and Sex Hormone Profiles in Females with Metabolic-Related Diseases

Table 6

The relationships between plasma asprosin level and metabolic and sex hormone profiles of PCOS females and the subgroups categorized by BMI.

	PCOS		PCOS (age-adjusted)		PCOS normal-weight(age-adjusted)		PCOS overweight/obese (age-adjusted)
	Age (years)	−0.118	0.463	—	—	—	—	—	—
BMI (kg/m^2)	0.201	0.207	0.150	0.365	0.276	0.411	−0.164	0.403
WHR	−0.087	0.590	0.083	0.609	−0.090	0.793	0.014	0.946
FBG (mmol/L)	0.148	0.355	0.636	0.000	−0.019	0.956	0.692	<0.001
FINS (mU/mL)	0.328	0.036	0.179	0.269	−0.079	0.818	0.090	0.649
OGTT-30 min insulin (mU/mL)	0.188	0.357	0.169	0.419	0.664	0.150	−0.016	0.949
EHCT-0 min-insulin (mU/mL)	0.699	0.002	0.456	0.076	0.541	0.636	0.365	0.244
EHCT-90 min-insulin (mU/mL)	0.429	0.086	0.311	0.240	−0.822	0.385	0.249	0.435
EHCT-180 min-insulin (mU/mL)	0.544	0.024	0.396	0.129	−0.344	0.776	0.385	0.216
HOMA-IR	0.429	0.005	0.544	0.000	−0.109	0.749	0.563	0.002
HOMA-β	−0.054	0.773	−0.026	0.875	−0.064	0.880	−0.229	0.319
HbA1c (%)	0.630	0.000	0.645	0.000	0.593	0.092	0.602	0.001
TG (mmol/L)	0.250	0.135	0.206	0.229	−0.315	0.447	0.233	0.242
TC (mmol/L)	0.226	0.178	0.389	0.019	0.322	0.422	0.327	0.096
LDL-c (mmol/L)	0.400	0.019	0.466	0.006	0.331	0.424	0.421	0.041
HDL-c (mmol/L)	−0.284	0.093	0.163	0.349	0.354	0.390	0.149	0.466
APOE (mg/dL)	0.310	0.070	0.503	0.002	0.521	0.150	0.464	0.022
APOB (g/L)	0.411	0.013	0.439	0.008	0.086	0.827	0.400	0.047
APOA1 (g/L)	−0.279	0.100	0.062	0.722	−0.317	0.406	0.078	0.711
T (nmol/L)	0.294	0.062	0.340	0.027	−0.118	0.729	0.379	0.047
FSH (mIU/L)	0.153	0.340	0.092	0.573	0.504	0.114	0.119	0.547
LH (mIU/L)	0.068	0.674	0.022	0.892	0.348	0.295	0.031	0.977
LH/FSH	−0.080	0.621	−0.063	0.698	−0.091	0.790	−0.077	0.697
E2 (pg/mL)	−0.091	0.570	−0.132	0.419	0.669	0.024	−0.304	0.116
P (ng/mL)	−0.195	0.221	−0.232	0.150	−0.271	0.420	−0.331	0.085
PRL (ng/mL)	−0.414	0.007	−0.39	0.013	−0.293	0.382	−0.464	0.013
SHBG (nmol/L)	−0.429	0.016	−0.247	0.188	−0.924	0.003	−0.115	0.610
DHEA-S (μg/dl)	0.042	0.833	0.166	0.407	0.836	0.078	0.379	0.090
17α-OHP (ng/mL)	0.044	0.853	0.011	0.966	0.855	0.145	0.018	0.952
AMH (ng/mL)	−0.202	0.407	−0.201	0.423	−0.938	0.062	−0.085	0,783
WBC (10^9/L)	0.112	0.504	0.102	0.546	0.050	0.899	0.026	0.897
CRP (mg/L)	−0.009	0.958	−0.002	0.989	0.209	0.619	0.124	0.547
TNF-α (pg/mL)	0.236	0.266	0.107	0.628	0.962	0.176	0.003	0.989
IL-6 (pg/mL)	0.449^∗	0.028	0.229	0.293	−0.474	0.686	0.174	0.477
IL-8 (pg/mL)	0.342	0.120	0.124	0.592	−0.447	0.705	0.052	0.481

Note: Correlations between variables were analyzed by Spearman’s correlation test and an age-adjusted partial correlation test. EHCT: euglycemic-hyperinsulinemic clamp test; SHBG: sex hormone-binding globulin; DHEA-S: dehydroepiandrosterone sulfate; 17α-OHP: 17-α-hydroxyprogesterone; AMH: anti-Mullerian hormone; TNF-α: tumor necrosis factor-α; IL-6: interleukin-6.