Activation of Macrophages by Oligomeric Proteins of Different Size and Origin

Table 2

Expression changes of cell-bound and secreted markers in macrophage cell model systems after treatment with M1- or M2-inducing factors.

Marker	J774		Macrophage primary cell culture		BV-2
	M1	M2	M1	M2	M1	M2
F4/80	High	High	High	High	High	High
CD68	High	—	—	—	High	—
CD86	High	Low	High	Low	High	—
IL-12	—	—	High	—	—	—
IL-23	High	—	High	—	—	—
TNF-α	High	—	High	—	—	Low
IL-10	—	—	—	—	—	—
CD206	—	High	—	High	—	High

M1: cells treated with IFN-γ/LPS; M2: cells treated with IL-4/IL-13; high: expression higher than in untreated cells; low: expression lower than in untreated cells; —: no changes in expression levels compared to untreated cells.