Research Article

Dynamics of Immune Responses during Experimental Mycobacterium kansasii Infection of Cynomolgus Monkeys (Macaca fascicularis)

Table 3

Results of comparisons with the beginning values and cytokine classification according to dynamic changes.

TypeDynamic characteristicNumberCytokinesCompared to the beginning by paired -test, falling within the range at week

1Sharp increase7TNF RII2, 4, 106, 12, 16
CXCL8/IL82, 4, 6, 1012, 16
IL106, 12, 162, 410
CCL5/RANTES162, 4, 10, 126
CXCL462, 10, 124, 16
CXCL106, 162, 4, 10, 12
CXCL132, 4, 6, 10, 1612

2Moderate increase8IFN-gamma2, 4, 126, 10, 16
TNF-alpha2, 4, 6, 10, 1612
GM-CSF2, 4, 6, 1012, 16
IL-1 beta4, 10, 12, 162, 6
IL42, 6, 12, 164, 10
IL17A2, 4, 610, 12, 16
CXCL12/SDF-1 alpha12, 162, 4, 6, 10
CD406, 104, 162, 12

3Slight increase8TNF RI2, 6, 164, 10, 12
IL262, 4, 10, 12, 16
IL152, 104, 6, 12, 16
IL222, 4, 6, 10, 12, 16
CCL24102, 6, 12, 16
CCL134, 62, 10, 12, 16
CCL2216122, 4, 6, 10
Galectin-3bp4, 6, 12, 162, 10

4A transient increase7IL624, 6, 10, 12, 16
CCL18246, 10, 12, 16
CCL272, 4, 6, 10, 12, 16
CXCL1/GRO alpha42, 6, 10, 12, 16
CD274, 102, 6, 12, 16
B7-H1/PD-L1/CD27442, 6, 10, 12, 16
MIF122, 4, 6, 10, 16

5Multipeak kinetics6IL1 RA6162, 4, 10, 12
IL1 RII24, 6, 10, 12, 16
IL23122, 4, 6, 10, 16
CCL42, 4, 6, 10, 12, 16
CCL7122, 4, 6, 10, 16
CCL114, 122, 6, 10, 16

6No specific changes8IL2 R alpha2, 4, 6, 10, 12, 16
IL52, 4, 6, 10, 12, 16
IL6 R alpha2, 4, 6, 10, 12, 16
IL192, 4, 6, 10, 12, 16
CD142, 4, 6, 10, 12, 16
CD302, 4, 6, 10, 12, 16
CD562, 4, 6, 10, 12, 16
MPO2, 4, 6, 10, 12, 16