Dynamics of Immune Responses during Experimental Mycobacterium kansasii Infection of Cynomolgus Monkeys (Macaca fascicularis)

Table 3

Results of comparisons with the beginning values and cytokine classification according to dynamic changes.

Type	Dynamic characteristic	Number	Cytokines	Compared to the beginning by paired -test, falling within the range at week
				1	Sharp increase	7	TNF RII		2, 4, 10	6, 12, 16
CXCL8/IL8		2, 4, 6, 10	12, 16
IL10	6, 12, 16	2, 4	10
CCL5/RANTES	16	2, 4, 10, 12	6
CXCL4	6	2, 10, 12	4, 16
CXCL10	6, 16	2, 4, 10, 12
CXCL13	2, 4, 6, 10, 16	12
2	Moderate increase	8	IFN-gamma		2, 4, 12	6, 10, 16
			TNF-alpha		2, 4, 6, 10, 16	12
			GM-CSF		2, 4, 6, 10	12, 16
			IL-1 beta		4, 10, 12, 16	2, 6
			IL4		2, 6, 12, 16	4, 10
			IL17A		2, 4, 6	10, 12, 16
			CXCL12/SDF-1 alpha		12, 16	2, 4, 6, 10
			CD40	6, 10	4, 16	2, 12
3	Slight increase	8	TNF RI		2, 6, 16	4, 10, 12
			IL2	6		2, 4, 10, 12, 16
			IL15		2, 10	4, 6, 12, 16
			IL22			2, 4, 6, 10, 12, 16
			CCL2	4	10	2, 6, 12, 16
			CCL13		4, 6	2, 10, 12, 16
			CCL22	16	12	2, 4, 6, 10
			Galectin-3bp		4, 6, 12, 16	2, 10
4	A transient increase	7	IL6		2	4, 6, 10, 12, 16
			CCL18	2	4	6, 10, 12, 16
			CCL27			2, 4, 6, 10, 12, 16
			CXCL1/GRO alpha		4	2, 6, 10, 12, 16
			CD27		4, 10	2, 6, 12, 16
			B7-H1/PD-L1/CD274	4		2, 6, 10, 12, 16
			MIF		12	2, 4, 6, 10, 16
5	Multipeak kinetics	6	IL1 RA	6	16	2, 4, 10, 12
			IL1 RII		2	4, 6, 10, 12, 16
			IL23		12	2, 4, 6, 10, 16
			CCL4			2, 4, 6, 10, 12, 16
			CCL7		12	2, 4, 6, 10, 16
			CCL11	4, 12		2, 6, 10, 16
6	No specific changes	8	IL2 R alpha			2, 4, 6, 10, 12, 16
			IL5			2, 4, 6, 10, 12, 16
			IL6 R alpha			2, 4, 6, 10, 12, 16
			IL19			2, 4, 6, 10, 12, 16
			CD14			2, 4, 6, 10, 12, 16
			CD30			2, 4, 6, 10, 12, 16
			CD56			2, 4, 6, 10, 12, 16
			MPO			2, 4, 6, 10, 12, 16