How Adhesion Molecule Patterns Change While Neutrophils Traffic through the Lung during Inflammation

Figure 2

Expression of CD11a (a) and CD11b (b) on PMNs in the different compartments of the lung. Mice were treated with LPS, and after 24 h, PMNs expressing CD11b on their surface were identified (% of frequency of parents) in the different compartments of the lung (IV = intravascular; ADHERENT = adherent to the endothelium; IS = interstitial; BAL = bronchoalveolar lavage). Next, the molecule expression of the adhesion molecule per PMN was analyzed by the determination of the mean fluorescence intensity (MFI). One representative histogram of the different MFIs of the adhesion molecule on PMNs in the different compartments of the lung is shown, whereas the red histogram resembles the negative control. Data are presented as mean ± SD; (a); (b); ; ; as indicated.

(a)

(b)