Quetiapine Attenuates the Neuroinflammation and Executive Function Deficit in Streptozotocin-Induced Diabetic Mice

Figure 3

QTP decreased TNF-α and MCP-1 production in brain hippocampal tissues of DM mice. (a) TNF-α was measured with the ELISA kit in the brain hippocampal tissues in the mice of all groups. The protein level of TNF-α in the STZ group was significantly higher than that in the control mice (), but the expression could be inhibited by QTP (). (b) MCP-1 was measured with the ELISA kit in the brain hippocampal tissues in the mice of all groups. The protein level of MCP-1 in the STZ group was significantly higher than that in the control mice (), but the expression could be inhibited by QTP (). All data were expressed as . vs. Cont; vs. STZ, .

(a)

(b)