Systematic Review with Meta-Analysis: Fecal Calprotectin as a Surrogate Marker for Predicting Relapse in Adults with Ulcerative Colitis

Table 1

Characteristics of the included studies.

Study	Year	Number of patients	Age (year)	Male (%)	FC assay	Standard of relapse	Follow-up time	Results
								TP	FP	FN	TN	Cutoff (μg/g)
Nakarai et al. [20]	2018	113	16–82	50%	PhiCal	WS, partial Mayo	2 y	34	26	14	39	75
Yamamoto et al. [21]	2018	164	31-39	61.59%	Cell Sciences	WS,	1 y	38	22	8	96	115
Keshteli et al. [22]	2017	20		45%	Bühlmann	WS, partial Mayo	1 y	5	2	2	11	124
Ferreiro-Iglesias et al. [23]	2016	20	19-68	40%	Bühlmann	WS, partial Mayo	8 w	4	3	0	13	198
Theede et al. [24]	2016	70		72.90%	Bühlmann	WS	1 y	7	8	8	47	321
Yamamoto et al. [27]	2015	80	18–74	58.80%	Cell Sciences	WS,	8 w	21	37	3	19	55
Scaioli et al. [26]	2015	74		72%	Calprest	WS, Mayo	1 y	13	1	7	53	193
Hosseini et al. [25]	2015	154		51.30%	Bühlmann	WS, Seo	1 y	59	9	15	71	341
Jauregui-Amezaga et al. [28]	2014	64		79%	Cerba Internacional	WS,	1 y	7	7	10	40	250
Yamamoto et al. [29]	2014	80		61%	Cell Sciences	WS,	1 y	16	14	5	45	170
De Vos et al. [30]	2013	87		45%	PhiCal	WS,	1 y	8	5	5	69	300
García-Sánchez et al. [33]	2010	69		59%	Calprest	WS, TW	1 y	17	18	4	20	120
Gisbert et al. [32]	2009	74		48%	PhiCal	WS, TW	1 y	9	16	4	45	164
Costa et al. [31]	2005	41	24-54	71%	Calprest	WS, Mayo	1 y	17	4	2	18	150

TP: true positive; FP: false positive; FN: false negative; TN: true negative; WS: worsening of symptoms; TW: modified Truelove-Witts score; ET, Edwards and Truelove score; MES: Mayo Endoscopic Subscore. PhiCal, Bühlmann, Cell Sciences, Calprest, and Cerba Internacional are different fecal calprotectin test kits.