Galanin Protects Rat Cortical Astrocyte from Oxidative Stress: Involvement of GalR2 and pERK1/2 Signal Pathway

<div>The protective effects of galanin against H<sub>2</sub>O<sub>2</sub>-induced toxicity in cultured rat cortical astrocytes. (a) Using CCK assay, treatment with 1 nM and 100 pM of galanin showed significantly protective effects against H<sub>2</sub>O<sub>2</sub>-induced toxicity; (b) treatment with galanin alone did not have any significant effects on the astrocyte viability compared to the control group; (c–f) galanin reversed the cell death induced by H<sub>2</sub>O<sub>2</sub>. Immunocytochemistry staining of GFAP in different groups: (c) control group, (d) 150 <i>μ</i>M H<sub>2</sub>O<sub>2</sub> group, (e) 150 <i>μ</i>M H<sub>2</sub>O<sub>2</sub>+1 nM galanin group, and (f) 1 nM galanin group. 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Mediators of Inflammation

fig2

Figure 2

Figure 2: Galanin Protects Rat Cortical Astrocyte from Oxidative Stress: Involvement of GalR2 and pERK1/2 Signal Pathway 