Computational and Biological Comparisons of Plant Steroids as Modulators of Inflammation through Interacting with Glucocorticoid Receptor

Table 1

Docking of plant steroids and fluticasone with the glucocorticoid receptor.

Ligands	GOLD score	Bonding interaction with amino acids
Glycyrrhetinic acid	55.3	ILE 255, PHE 357
Guggulsterone	51.3	LYS 359, ASP 256
Boswellic acid	45.6	LYS 359, ILE 255, THR 232, ASP 256, PHE 357, TRP 362
Withaferin A	54.9	ASP 256, LYS 359, ARG 10, TRP 362
Diosgenin	53.3	GLN 570, MET 604, MET 646, ASN 564, THR 739, PHE 749
Fluticasone	61.8	ASP 256, VAL 17, LYS 359, TRP 362