Research Article

Computational and Biological Comparisons of Plant Steroids as Modulators of Inflammation through Interacting with Glucocorticoid Receptor

Table 2

Effect of plant steroids and fluticasone on the percent of increase in ear weight in a croton oil-induced ear edema model and the granuloma weight in the cotton pellet-induced-granuloma model.

LigandsIncrease in ear weight (%)Granuloma weight (mg)

PC
PC-GA
PC-GS
PC-BA
PC-WA
PC-DG
PC-FC

Values were expressed as () and analyzed by one-way ANOVA followed by Tukey’s test. Results were considered significant if values were less than 0.5. Significance was reported when values were <0.05 (), <0.01 (), or <0.001 () compared with the positive control (PC). PC-GA: PC treated with glycyrrhetinic acid; PC-GS: PC treated with guggulsterone; PC-BA: PC treated with boswellic acid; PC-WA: PC treated with withaferin A; PC-DG: PC treated with diosgenin; PC-FC: PC treated with fluticasone.