Alleviation of Hepatic Ischemia Reperfusion Injury by Oleanolic Acid Pretreating via Reducing HMGB1 Release and Inhibiting Apoptosis and Autophagy

<div>OA preconditioning alleviates hepatic IRI biochemically and histopathologically. (a) Serum ALT and AST levels at 2, 8, and 24 h after hepatic IR detected by ELISA. (b) H&amp;E staining of the liver specimens collected at three time points. Scale bar: 200 <i>μ</i>m. The black arrow indicates the necrotic area, the yellow arrow represents edema, and the blue arrow indicates leukocyte infiltration. The areas of necrosis and edema were quantified with Image-Pro Plus 6.0 (original magnification, ×200). 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Mediators of Inflammation

fig1

Figure 1

Figure 1: Alleviation of Hepatic Ischemia Reperfusion Injury by Oleanolic Acid Pretreating via Reducing HMGB1 Release and Inhibiting Apoptosis and Autophagy 

Figure 1 | Alleviation of Hepatic Ischemia Reperfusion Injury by Oleanolic Acid Pretreating via Reducing HMGB1 Release and Inhibiting Apoptosis and Autophagy 