Alleviation of Hepatic Ischemia Reperfusion Injury by Oleanolic Acid Pretreating via Reducing HMGB1 Release and Inhibiting Apoptosis and Autophagy

Figure 4

A schematic diagram of the mechanism underlying the hepatoprotective effect of OA on liver IR. In our hepatic IR model, OA inhibits TNF-α-mediated JNK phosphorylation, thereby decreasing hepatocellular apoptosis and autophagy by promoting Bcl-2 activity and suppressing the expression of caspase-9 induced by Bax and Beclin 1 activation. OA reduces the production of the late inflammatory mediator HMGB1, alleviating hepatic IRI.