FTY720 Effects on Inflammation and Liver Damage in a Rat Model of Renal Ischemia-Reperfusion Injury

<div>FTY720 treatment alters kinetics of peripheral leukocytes following renal ischemia. Rats underwent renal ischemia by the surgical placement of a microvascular clamp around the left renal pedicle of the anesthetized rat. Rats received a single intravenous bolus of either vehicle control (black circle) or 0.3 mg/kg FTY720 (gray square) 15 min after placement of the clamp. Vehicle control and FTY720 groups were euthanized at 6, 24, or 72 hrs. Peripheral blood CBC analysis was performed on blood collected by cardiac puncture. 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Mediators of Inflammation

fig2

Figure 2

Figure 2: FTY720 Effects on Inflammation and Liver Damage in a Rat Model of Renal Ischemia-Reperfusion Injury 