FTY720 Effects on Inflammation and Liver Damage in a Rat Model of Renal Ischemia-Reperfusion Injury

Figure 4

FTY720 treatment reduces hepatocellular degeneration compared to vehicle controls. Formalin-fixed paraffin-embedded liver and ischemic kidney tissue was stained with hematoxylin and eosin at 6, 24, and 72 hrs. Digital bright-field images were taken at 40x total magnification and analyzed by a pathologist using a previously established scoring system. Vehicle control (black circle) and FTY720 treatment (gray square) at the indicated time points postinjury. compared with vehicle control at the same time point postinjury. Representative images of the liver at 24 hrs for vehicle control-treated (b) and FTY720-treated (c) rats. Arrow pointing to hepatocellular degeneration (b). Representative images of the ischemic kidney at 24 hrs for vehicle control-treated (d) and FTY720-treated (e) rats. (f) Comparison of renal congestion between vehicle control (black circle) and FTY720-treated (gray square) rats.

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