Interleukin 10 Gene-Modified Bone Marrow-Derived Dendritic Cells Attenuate Liver Fibrosis in Mice by Inducing Regulatory T Cells and Inhibiting the TGF-β/Smad Signaling Pathway

<div>Immune-histochemical analysis of α-SMA in liver sections (magnification, ×200). DC-IL10 treatment markedly decreased the α-SMA expression compared with the model group and DC-mock treatment group. HSCs: hepatic stellate cells; α-SMA: α-smooth muscle actin. G1: control group; G2: model group; G3: DC-mock-treated group; G4: DC-IL10-treated group.</div>

Mediators of Inflammation

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Figure 9

Figure 9: Interleukin 10 Gene-Modified Bone Marrow-Derived Dendritic Cells Attenuate Liver Fibrosis in Mice by Inducing Regulatory T Cells and Inhibiting the TGF-β/Smad Signaling Pathway

Figure 9 | Interleukin 10 Gene-Modified Bone Marrow-Derived Dendritic Cells Attenuate Liver Fibrosis in Mice by Inducing Regulatory T Cells and Inhibiting the TGF-β/Smad Signaling Pathway 