miR-657 Promotes Macrophage Polarization toward M1 by Targeting FAM46C in Gestational Diabetes Mellitus

Figure 1

miR-657 is increased and positively associated with M1 markers of placental macrophages in GDM. (a) Increased expression of miR-657 in GDM placental macrophages compared with controls (; , 30/29). (b) mRNA level of IL-12 in GDM placental macrophages in contrast to normal controls (; , 30/29). (c) mRNA level of TNF-α in GDM placental macrophages compared with normal pregnancies (; , 30/29). (d) mRNA level of Arginase 1 in placental macrophages of GDM pregnancies in contrast to controls (; , 30/29). (e) mRNA level of CD206 in placental macrophages of GDM pregnancies compared with controls (; , 30/29). (f) Positive association between miR-657 and IL-12 in GDM placental macrophages (). (g) Positive association between miR-657 and TNF-α in GDM placental macrophages ().

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