miR-657 Promotes Macrophage Polarization toward M1 by Targeting FAM46C in Gestational Diabetes Mellitus

Figure 2

miR-657 is associated with the polarization of macrophages in GDM. (a) mRNA expression of IL-12, TNF-α, CD206, and Arginase 1 in miR-657 mimics treated macrophages (; ; representative data of three independent experiments). (b) Expression of IL-12 and TNF-α in the supernatant of miR-657 mimics treated THP-1 cells (; data of three repeated experiments). (c) Expression of CD206 protein in THP-1 cells determined by western blot (representative picture of three independent tests). (d) Arginase 1 is decreased in miR-657 mimics treated THP-1 cells as evidenced by immunofluorescence (representative picture of three independent detections).

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