Progressive Increase of Inflammatory CXCR4 and TNF-Alpha in the Dorsal Root Ganglia and Spinal Cord Maintains Peripheral and Central Sensitization to Diabetic Neuropathic Pain in Rats

Figure 3

STZ-induced DNP increased the spinal cord dorsal CXCR4 and TNF-α of spinal cord dorsal horn at 5 weeks but not at 2 weeks of diabetes. (a, b) CXCR4 and TNF-α expression in spinal cord dorsal horn, as shown by western blotting, at 2 and 5 weeks after intravenous STZ and control. (c, d) Quantification of CXCR4 and TNF-α in spinal cord. The western blot results are presented as (, compared with control group, Student’s -test, ).

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