IGF-1R Inhibition Suppresses Cell Proliferation and Increases Radiosensitivity in Nasopharyngeal Carcinoma Cells

Figure 1

pIGF-1R was activated by ionizing radiation, and linsitinib suppressed cell proliferation in NPC cells. (a) Basal levels of total and phosphorylated IGF-1R in NPC cell lines. (b) Linsitinib suppressed NPC cell proliferation. CNE-2 and SUNE-1 cells were incubated with increasing concentrations of linsitinib, and cell growth was determined after 72 h treatment by MTT assay. (c) CNE-2 and SUNE-1 cells were treated with IR. Cell lysates were harvested at 24 h post irradiation, and the indicated proteins were determined by Western blotting.

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