Hepcidin and Iron Homeostasis in Patients with Subacute Thyroiditis and Healthy Subjects

Table 1

Biochemical parameters in patients with subacute thyroiditis (SAT) at baseline (T0) compared to healthy control subjects (CS).

Parameter	Reference range	SAT (T0)	CS	value
HepcidinEL (ng/mL)	0.2-47.7	48.8 (15.9-74.5)	18.2 (10.2-23.3)	0.009^1
WBC (×10^3/μL)	3.9-11.0	8.2 (7.1-9.1)	6.7 (5.2-8.7)	NS^1
RBC (×10^6/μL)	3.5-5.2			0.032^2
HGB (g/dL)	12.0-15.6			<0.001^2
HCT (%)	33.0-46.0			<0.001^2
MCV (fL)	80.0-99.0			<0.001^2
MCH (pg)	27.0-33.5	29.4 (28.2-29.7)	30.8 (30.0-31.8)	<0.001^1
MCHC (g/dL)	31.0-38.0	33.0 (32.6-33.6)	33.9 (33.3-34.3)	0.002^1
RDW-CV (%)	11.0-16.0	12.1 (11.7-12.4)	12.9 (12.8-13.4)	<0.001^1
PLT (×10^3/μL)	130.0-400.0			<0.001^2
PDW (fL)	9.0-17.0			0.013^2
MPV (fL)	9.0-13.0			0.009^2
P-LCR (%)	13.0-43.0			0.013^2
CRP (mg/L)	<5.0	38.5 (12.2-50.9)	1.6 (0.6-3.6)	<0.001^1
ALT (U/L)	10.0-41.0	18.0 (11.0-24.0)	21.0 (14.0-24.0)	NS^1
AST (U/L)	10.0-37.0	17.0 (13.0-20.0)	19.0 (26.0-23.0)	NS^1
TSH (μIU/mL)	0.2-4.2	0.02 (0.01-0.08)	1.2 (1.0-1.6)	<0.001^1
fT3 (pmol/L)	3.9-6.7			<0.001^2
fT4 (pmol/L)	11.5-21.0	28.4 (23.0-39.4)	16.1 (14.8-18.0)	<0.001^1
aTPO (IU/mL)	<34.0	14.0 (9.0-20.0)	13.0 (10.0-16.0)	NS^1
aTG (IU/mL)	10.0-115.0	33.0 (19.0-84.0)	13.5 (10.0-24.0)	0.012^1
TRAb (IU/L)	<2.0	0.3 (0.2-0.5)	0.3 (0.2-0.4)	NS^1
Ferritin (ng/mL)	13.0-150.0	115 (48.0-197.0)	88.0 (44.0-125.0)	NS^1
Fe (μg/dL)	37.0-145.0	37.0 (29.0-70.0)	98.0 (70.0-139.0)	<0.001^1
Creatinine (mg/dL)	0.5-1.2	0.6 (0.5-0.7)	0.7 (0.70.8)	NS^1

Values are expressed as median (IQR) for nonparametric tests and for parametric tests. ¹Mann–Whitney test; ²independent -test. Parameters with different reference ranges in men and women, test performed only in the female subgroup. NS: nonsignificant; WBC: white blood cells; RBC: red blood cells; HGB: haemoglobin; HCT: haematocrit; MCV: mean corpuscular volume; MCH: mean corpuscular haemoglobin; MCHC: mean corpuscular haemoglobin concentration; RDW-CV: red blood cell distribution width-coefficient of variation; PLT: platelets; PDW: platelet distribution width; MPV: mean platelet volume; P-LCR: platelet larger cell ratio; CRP: C-reactive protein; ALT: alanine aminotransferase; AST: aspartate aminotransferase; TSH: thyroid-stimulating hormone; fT3: free triiodothyronine; fT4: free thyroxine; aTPO: anti-thyroid peroxidase antibody; aTG: anti-thyroglobulin antibody; TRAb: thyrotropin receptor antibody; Fe: iron.