Mediators of Inflammation

Research Article

Hepcidin and Iron Homeostasis in Patients with Subacute Thyroiditis and Healthy Subjects

Table 2

Biochemical parameters in patients with subacute thyroiditis (SAT) at baseline (T0) compared to the values obtained following complete remission of the disease (T1). Only parameters demonstrating statistically significant differences are presented.
ParameterReference rangeSAT baseline (T0)SAT follow-up (T1) value
HepcidinEL (ng/mL)0.2-47.748.8 (15.9-74.5)4.0 (1.2-10.0)<0.0011
WBC (×103/μL)3.9-11.0<0.0012
RBC (×106/μL)3.5-5.20.0022
HGB (g/d)12.0-15.6<0.0012
HCT (%)33.0-46.00.0032
MCH (pg)27.0-33.529.4 (28.2-29.7)29.3 (28.5-30.7)0.0041
MCHC (g/dL)31.0-38.033.0 (32.6-33.6)33.9 (33.3-34.5)0.0071
RDW-CV (%)11.0-16.012.1 (11.7-12.4)13.5 (12.7-14.5)<0.0011
PLT (×103/μL)130.0-400.0<0.0012
PDW (fL)9.0-17.00.0012
MPV (fL)9.0-13.0<0.0012
P-LCR (%)13.0-43.0<0.0012
CRP (mg/L)<5.038.5 (12.2-50.9)1.0 (0.5-2.0)<0.0011
TSH (μU/mL)0.2-4.20.02 (0.01-0.1)1.2 (0.7-2.0)<0.0011
fT3 (pmol/L)3.9-6.7<0.0012
fT4 (pmol/L)11.5-21.028.4 (23.0-39.4)15.2 (14.6-16.8)<0.0011
TRAb (IU/L)<0.20.3 (0.2-0.5)0.2 (0.1-0.3)0.0151
Ferritin (ng/mL)13.0-150.0115 (48.0-197.0)34.5 (25.0-43.0)<0.0011
Fe (μg/dL)37.0-145.037.0 (29.0-70.0)98.5 (65.0-111.0)0.0011
Values are expressed as median (IQR) for nonparametric tests and for the parametric test. 1Wilcoxon test; 2dependent -test, parameters with different reference ranges in men and women, test performed only in the female subgroup. WBC: white blood cells; RBC: red blood cells; HGB: haemoglobin; HCT: haematocrit; MCH: mean corpuscular haemoglobin; MCHC: mean corpuscular haemoglobin concentration; RDW-CV: red blood cell distribution width-coefficient of variation; PLT: platelets; PDW: platelet distribution width; MPV: mean platelet volume; P-LCR: platelet larger cell ratio; CRP: C-reactive protein; TSH: thyroid-stimulating hormone; fT3: free triiodothyronine; fT4: free thyroxine; TRAb: thyrotropin receptor antibody; Fe: iron.