Evidence That the Anti-Inflammatory Effect of Rubiadin-1-methyl Ether Has an Immunomodulatory Context

Table 1

Effects of Rubiadin-1-methyl ether on pro- and anti-inflammatory cytokine levels in LPS-induced acute lung injury (ALI) in mice.

Cytokines	TNF-α (pg/mL)	IL-6 (pg/mL)	MCP-1 (pg/mL)	IL-12p70 (pg/mL)	INF-γ (pg/mL)	IL-10 (pg/mL)
S
LPS
Dexa
Rub (3)
Rub (10)
Rub (30)

S: health animals treated with vehicle per oral 0.5 h before intranasal instillation with sterile saline; LPS: negative control, also pretreated with vehicle and induced by LPS (5 mg/kg); Dexa: positive control, pretreated with Dexamethasone (5 mg/kg) per oral administrated 0.5 h before acute lung injury induction; Rub: treatment with Rubiadin-1-methyl ether (3, 10, and 30 mg/kg) administered per oral 0.5 h before LPS-induced acute lung injury. Each group represents the ; animals; ; ; .