Neuroprotective Effects of Collagen-Glycosaminoglycan Matrix Implantation following Surgical Brain Injury

Figure 4

Early decrease of TUNEL⁺ cells in the lesion boundary zone (LBZ) of surgical brain lesions following implantation of the collagen-glycosaminoglycan (CG) matrix. (a) Representative microphotographs of double immunofluorescence staining of representative brain sections from the sham (SHAM), surgery-induced brain lesion (L), and CG matrix implantation following surgery-induced lesion cavity (L+CG) groups on day 14 following surgical brain trauma. In the image of immunoreactivity, TUNEL (green) was used to quantify the apoptotic cells in the SHAM, L, and L+CG groups. (b) Number of TUNEL⁺ cells in the LBZ in brain sections from the SHAM, L, and L+CG groups on days 7, 14, 21, and 28 after surgery. Data are presented as the . , , and vs. the SHAM group; , , and vs. the L+CG group.

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