Oscillatory Shear Stress Induces Oxidative Stress via TLR4 Activation in Endothelial Cells

Figure 7

A schematic of how OSS promote oxidative stress through TLR4 activation. TLR4 modulates OSS-induced oxidative stress via two distinct mechanisms. First, it promotes the transfer of p47 from the cytoplasm to the cell membrane, activating NOX2. Second, it phosphorylates caveolin-1 and promotes the association of eNOS with caveolin-1, resulting in eNOS deactivation.