Interleukin-7 Resensitizes Non-Small-Cell Lung Cancer to Cisplatin via Inhibition of ABCG2

Figure 5

Both IL-7R knockdown and PI3K activation inhibited the synergetic effect by IL-7 on the apoptosis and cell cycle arrest induced by DDP. After being pretreated with si IL-7R or NC transfection, or 740 Y-P (10 nM), the A549/DDR cells were exposed to IL-7 (2 ng/mL) and DDP (0.5 μg/mL). At 48 h after the combinational treatment, the cell apoptosis was determined by Hoechst staining (a) and flow cytometry (b, d) and the cell cycle was also examined by flow cytometry (c, e). NC means cells were pretreated with negative control siRNA. and , as compared with the cells pretreated with the control. Data are presented in terms of .

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