Research Article
Enhanced Activity by NKCC1 and Slc26a6 Mediates Acidic pH and Cl− Movement after Cardioplegia-Induced Arrest of db/db Diabetic Heart
Figure 7
Schematic model of involvement of ion transporters followed by cardioplegia-induced arrest and ion imbalance in the db/db heart. Enhanced Slc26a6 and NKCC1 the in db/db heart may be involved in dysregulated pHi and Cl− modulation after cardioplegia-induced arrest. Abbreviation: NHE: Na+-H+ exchanger; Slc26a6: solute carrier transporter 26 family a6; NKCC1: Na+-K+-2Cl− cotransporter 1; CA IV: carbonic anhydrase IV.