Neutrophil Extracellular Trap Components Associate with Infarct Size, Ventricular Function, and Clinical Outcome in STEMI
Table 2
Crude and multivariable adjusted odds ratio (OR) for large final infarct size.
OR
95% CI
value
Univariate analyses
High dsDNA on day 11
2.9
1.5–5.4
0.001
Age, per year
0.99
0.96–1.02
0.400
Male gender
3.3
1.2–8.7
0.017
Time, symptoms to PCI (ln), per SD
1.2
0.9–1.6
0.275
Anterior MI
8.2
4.0–16.8
<0.001
Ischemic postconditioning
0.4
0.2–0.8
0.007
Total cholesterol (mmol/l), admission
0.94
0.72–1.23
0.668
Peak CRP (ln), per SD
3.6
2.3–5.6
<0.001
CRP after 4 months (ln), per SD
1.2
0.9–1.6
0.163
Peak troponin T (ln), per SD
21.3
9.3–48.9
<0.001
Multivariable analyses
Model 1
High dsDNA on day 11
2.3
1.1–4.6
0.021
Male gender
2.7
0.9–7.9
0.078
Time, symptoms to PCI (ln), per SD
1.4
0.96–1.99
0.082
Anterior MI
7.3
3.4–15.6
<0.001
Ischemic postconditioning
0.4
0.2–0.8
0.007
Model 2
High dsDNA on day 11
1.4
0.6–3.1
0.458
Male gender
4.1
1.1–15.3
0.037
Time, symptoms to PCI (ln), per SD
1.4
0.9–2.2
0.095
Anterior MI
5.5
2.4–12.8
<0.001
Ischemic postconditioning
0.3
0.1–0.6
0.003
Peak CRP (ln), per SD
3.1
1.9–5.1
<0.001
Model 3
High dsDNA on day 11
0.7
0.3–1.8
0.456
Male gender
1.5
0.4–6.1
0.535
Time, symptoms to PCI (ln), per SD
1.1
0.7–1.7
0.744
Anterior MI
3.1
1.3–7.7
0.014
Ischemic postconditioning
0.3
0.1–0.8
0.012
Peak troponin T (ln), per SD
16.6
6.5–42.2
<0.001
Large final infarct size is defined as >75th percentile (>22.8% of LV volume) at CMR 4 months after the STEMI. 1>median (366 ng/ml). CI: confidence interval. CRP: C-reactive protein. dsDNA: double-stranded deoxyribonucleic acid. ln: natural logarithm. MI: myocardial infarction. PCI: percutaneous coronary intervention. SD: standard deviation.
