Neutrophil Extracellular Trap Components Associate with Infarct Size, Ventricular Function, and Clinical Outcome in STEMI

Table 3

Crude and multivariable adjusted odds ratio (OR) for reduced LVEF after 4 months.

	OR	95% CI	value
Univariate analyses
High dsDNA levels on day 1^1	3.7	2.0–6.8	<0.001
Age, per year	1.00	0.97–1.02	0.760
Male gender	3.7	1.4–9.7	0.009
Time, symptoms to PCI (ln), per SD	1.4	1.0–1.9	0.026
Anterior MI	3.6	2.0–6.5	<0.001
Ischemic postconditioning	0.9	0.5–1.5	0.641
Multivessel disease	0.9	0.5–1.6	0.667
Peak CRP (ln), per SD	3.1	2.1–4.6	<0.001
CRP after 4 months (ln), per SD	1.5	1.2–2.0	0.006
Peak troponin T (ln), per SD	10.5	5.6–20.0	<0.001
Multivariable analyses
Model 1
High dsDNA levels on day 1^1	3.0	1.6–5.7	0.001
Male gender	2.9	1.0–8.3	0.048
Time, symptoms to PCI (ln), per SD	1.5	1.1–2.1	0.022
Anterior MI	3.0	1.6–5.8	0.001
Model 2
High dsDNA levels on day 1^1	2.1	0.99–4.33	0.052
Male gender	3.1	0.95–10.09	0.061
Time, symptoms to PCI (ln), per SD	1.5	1.0–2.2	0.042
Anterior MI	2.8	1.3–5.9	0.008
Peak CRP (ln), per SD	2.2	1.4–3.4	<0.001
CRP after 4 months (ln), per SD	1.4	0.96–1.95	0.085
Model 3
High dsDNA levels on day 1^1	1.4	0.6–3.0	0.442
Male gender	2.2	0.6–7.2	0.212
Time, symptoms to PCI (ln), per SD	1.3	0.9–1.9	0.215
Anterior MI	1.2	0.5–2.6	0.692
Peak troponin T (ln), per SD	7.9	3.9–15.8	<0.001

Reduced LVEF is defined as measured by CMR 4 months after STEMI. ¹>median (366 ng/ml). CI: confidence interval. CRP: C-reactive protein. dsDNA: double-stranded deoxyribonucleic acid. ln: natural logarithm. MI: myocardial infarction. PCI: percutaneous coronary intervention. SD: standard deviation.