Preoperative Sleep Disturbance Exaggerates Surgery-Induced Neuroinflammation and Neuronal Damage in Aged Mice

<div>Preoperative sleep disturbance enhanced microglial activation in the hippocampus induced by the tibial surgery. (a) Representative immunohistochemistry images of microglia (red arrows) in areas CA1 and CA3 of the hippocampus based on staining with an anti-Iba1 antibody. Scale bar: 100 <i>μ</i>m. (b) Quantification of Iba1-positive cells in areas CA1 and CA3 of the hippocampus. (c) Expression levels of Iba1 protein in the hippocampus. 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Mediators of Inflammation

fig4

Figure 4

Figure 4: Preoperative Sleep Disturbance Exaggerates Surgery-Induced Neuroinflammation and Neuronal Damage in Aged Mice 