Preoperative Sleep Disturbance Exaggerates Surgery-Induced Neuroinflammation and Neuronal Damage in Aged Mice

Figure 6

Preoperative sleep disturbance augmented surgery-induced neuronal activation and apoptosis in the hippocampus. (a, b) Representative immunohistochemistry images of neuronal damage based on staining with anti-c-fos and anti-caspsase-3 antibody in areas CA1 and CA3 of the hippocampus. Scale bar: 100 μm. (c, d) Quantification of c-fos-positive and caspsase-3-positive cells in areas CA1 and CA3 of the hippocampus. The data are presented as the (). and vs. the Con group; and vs. the Sur group.

(a)

(b)

(c)

(d)