Preoperative Sleep Disturbance Exaggerates Surgery-Induced Neuroinflammation and Neuronal Damage in Aged Mice

<div>Preoperative sleep disturbance augmented operation-induced blood-brain barrier disruption. (a) EB content and the protein levels of albumin in the hippocampus. (b) Expression levels of occludin and claudin-5 protein in the hippocampus. (c) Expression levels of MMP-2 and MMP-9 protein in the hippocampus. 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Mediators of Inflammation

fig7

Figure 7

Figure 7: Preoperative Sleep Disturbance Exaggerates Surgery-Induced Neuroinflammation and Neuronal Damage in Aged Mice 