The Role of Long-Chain Fatty Acids in Inflammatory Bowel Disease

Table 3

Effects of LCFAs in the resolving phase in IBD.

Resolving phase	The type of LCFAs	Role
Neutrophil trafficking	RvE1, RvD2, LXA4, and MaR1	Inhabit PMN infiltration
Apoptosis and phagocytosis	Resolvins from n-6 and n-3 PUFAs	Promote phagocytosis of macrophages, polarize macrophages towards M2 phenotype
	RvD1	Promote phagocytosis of apoptotic macrophages
	LXA4	Promote phagocytosis of apoptotic macrophages and neutrophils
	RvE1	Promote phagocytosis of apoptotic neutrophils
	Protectin D1	Promote phagocytosis of apoptotic neutrophils