Increased Soluble Epoxide Hydrolase in Human Gestational Tissues from Pregnancies Complicated by Acute Chorioamnionitis

Figure 5

LPS led to increased sEH mRNA and protein levels in fetal membrane and villous explants. Compared to the vehicle controls, the administration of LPS to the culture medium led to a significant increase in the levels of sEH mRNA and protein in the amnion and choriodecidua, respectively, with the two-chamber culture system (a, b, d, and e). Similar effects of LPS on the expression of sEH was also observed in villous explants (c and f). β-Actin was used to normalize loading variability. Data are presented as , for each group. and compared with the vehicle control by Student’s -test.

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