A Peptide Analogue of Selectin Ligands Attenuated Atherosclerosis by Inhibiting Monocyte Activation

Figure 3

IELLQAR decreases atherosclerotic lesions in WTD-induced mice. Eight-week-old male ApoE^-/- mice were randomized into one of three treatment groups: IELLQAR (1 or 3 mg/kg) or vehicle. All mice were fed a high-fat diet for 12 weeks. (a) Representative images of Oil red O staining of the whole aorta after en face preparation and quantification of lipid content (lipid content/vascular area) (). (b) Representative histological analysis results of the aortic sinus following H&E, Masson’s trichrome, and Movat staining and quantification of the plaque area (plaque area/lumen area), collagen content (collagen content/plaque area), and necrotic area (necrotic area/plaque area) in the aortic sinus (). Scale bar: 200 μm. Data are presented as the . , , and .

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