Inhibition of Peptidyl Arginine Deiminase-4 Prevents Renal Ischemia-Reperfusion-Induced Remote Lung Injury

Figure 1

Kidney and pulmonary histopathological changes and lung PAD4 activity in renal ischemia-reperfusion- (IR-) treated mice. (a) Representative photographs of H&E-stained kidney samples from 24 h after renal IR injury (scale bar: 50 μm). (b, c) Determination of blood urea nitrogen (BUN) and creatinine levels. (d) Representative photographs of H&E-stained lung sections from 24 h after renal IR injury (scale bar: 50 μm). (e) Histological analysis of lung sections. (f) The PAD4 mRNA expression measured by quantitative RT-PCR. (g) The PAD4 expression evaluated by immunohistochemistry (scale bar: 50 μm). (h) Analysis of the PAD4 expression. The values are the ; ; and .

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