CXCL14 Overexpression Attenuates Sepsis-Associated Acute Kidney Injury by Inhibiting Proinflammatory Cytokine Production

Figure 6

CXCL14 overexpression inhibited M1 polarization and improved M2 polarization in vivo and in vitro. (a) Renal iNOS and (b) Arg-1 mRNA expressions were determined by RT-PCR. RAW264.7 received lentivirus infections for 48 hours and were then treated with lipopolysaccharides (LPS, 100 ng/ml, 8 h) or IL-4 (10 ng/ml, 12 h). Then, (c) TNF-α and (d) IL-10 expressions were measured by ELISA kits. (e) iNOS and (f) Arg-1 mRNA expressions were determined by RT-PCR.

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