Intravenous Arginine Administration Downregulates NLRP3 Inflammasome Activity and Attenuates Acute Kidney Injury in Mice with Polymicrobial Sepsis

Figure 1

Plasma arginine, glutamine, citrulline, and proline concentrations of the normal and experimental groups. NC: normal control group; Sham: sham group; SS: sepsis group with saline injection sacrificed at 6, 12, and 24 h after cecal ligation and puncture (CLP); SA: sepsis group with arginine injection sacrificed at 6, 12, and 24 h after CLP. Results are presented as the ; for each group. Differences between groups were analyzed with a one-way ANOVA with Tukey’s post hoc test. Significantly differs from the NC group; ^#significantly differs from the SS groups at the same time point ().

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