Mediators of Inflammation

Research Article

Associations between Interleukin Gene Polymorphisms and Risks of Developing Extremity Posttraumatic Osteomyelitis in Chinese Han Population

Table 1

Comparisons of genotype distribution, allele frequency, and genetic models of rs16944, rs1143627, rs4251961, and rs1800796 between PTOM patients and healthy controls.


SNP	Item		Patients	Controls	Test statistics	values	(95% CI)

rs16944	Genotype (, %)	AA	30 (15.87)	52 (26.0)	6.012	0.049
		AG	98 (51.85)	90 (45.0)
		GG	61 (32.28)	58 (29.0)
	Allele frequency	G vs. A	220/158	206/194	3.523	0.061	1.311 (0.988-1.741)
	Dominant model	GG+AG vs. AA	159/30	148/52	5.733	0.017	1.854 (1.118-3.073)
	Recessive model	GG vs. AA+AG	61/128	58/142	0.555	0.456	1.180 (0.764-1.822)
	Homozygous model	GG vs. AA	61/30	58/52	4.184	0.041	1.831 (1.026-3.267)
	Heterozygous model	AG vs. AA	98/30	90/52	5.225	0.022	1.869 (1.093-3.194)

rs1143627	Genotype (, %)	CC	31 (16.40)	51 (25.5)	4.928	0.085
		CT	97 (51.32)	94 (47.0)
		TT	61 (32.28)	55 (27.5)
	Allele frequency	T vs. C	219/159	204/196	3.769	0.052	1.323 (0.997-1.756)
	Dominant model	TT+CT vs. CC	158/31	149/51	4.615	0.032	1.735 (1.050-2.868)
	Recessive model	TT vs. CC + CT	61/128	55/145	1.202	0.273	1.278 (0.824-1.981)
	Homozygous model	TT vs. CC	61/31	55/51	4.229	0.040	1.839 (1.029-3.285)
	Heterozygous model	CT vs. CC	97/31	94/51	3.606	0.058	1.675 (0.984-2.853)

rs4251961	Genotype (, %)	TT	167 (88.36)	155 (77.5)	8.967	0.007
		CT	19 (10.05)	42 (21.0)
		CC	3 (1.59)	3 (1.5)
	Allele frequency	C vs. T	25/353	48/352	6.631	0.010	0.519 (0.313-0.861)
	Dominant model	CC+CT vs. TT	22/167	45/155	7.980	0.005	0.446 (0.254-0.781)
	Recessive model	CC vs. TT+CT	3/186	3/197	0.038	0.845	1.177 (0.231-6.007)
	Homozygous model	CC vs. TT	3/167	3/155	0.000	0.985	1.016 (0.198-5.214)
	Heterozygous model	CT vs. TT	19/167	42/155	8.844	0.003	0.409 (0.227-0.737)

rs1800796	Genotype (, %)	GG	3 (1.59)	12 (6.0)
		CG	58 (30.69)	64 (32.0)	5.452	0.065
		CC	128 (67.72)	124 (62.0)
	Allele frequency	C vs. G	314/64	312/88	3.176	0.075	1.384 (0.967-1.980)
	Dominant model	CC+CG vs. GG	186/3	188/12	4.745	0.029	4.184 (1.154-15.165)
	Recessive model	CC vs. GG+CG	128/61	124/76	1.433	0.231	1.295 (0.848-1.979)
	Homozygous model	CC vs. GG	128/3	124/12	4.983	0.026	4.378 (1.197-16.007)
	Heterozygous model	CG vs. GG	58/3	64/12	3.984	0.046	3.834 (1.024-14.347)

PTOM: posttraumatic osteomyelitis; OR: odds ratio; CI: confidence interval.