Understanding Human Cerebral Malaria through a Blood Transcriptomic Signature: Evidences for Erythrocyte Alteration, Immune/Inflammatory Dysregulation, and Brain Dysfunction

<div>Gene network and upstream analysis by Ingenuity Pathway Analysis (IPA; Qiagen Inc.). Gene network highlighting the candidate genes and their interaction with the genes presented as nodes and relationship between two indicated as a line. Upstream regulator analysis allows the identification of transcriptional regulators and their target genes dysregulated in our dataset. (a) Gene network for connective tissue development and function, tissue morphology, and connective tissue disorders. (b) Gene network for cell death and survival, connective tissue disorders, and hematological disease. (c) The transcriptional regulator TNF was ranked first among the upstream regulators, and 38 genes were predicted to be activated or inhibited by TNF. Four additional upstream regulators SLC4A1, IL-1B, STAT3, and IL-6 have been identified.</div>

Mediators of Inflammation

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Figure 2: Understanding Human Cerebral Malaria through a Blood Transcriptomic Signature: Evidences for Erythrocyte Alteration, Immune/Inflammatory Dysregulation, and Brain Dysfunction 

Figure 2 | Understanding Human Cerebral Malaria through a Blood Transcriptomic Signature: Evidences for Erythrocyte Alteration, Immune/Inflammatory Dysregulation, and Brain Dysfunction 