Understanding Human Cerebral Malaria through a Blood Transcriptomic Signature: Evidences for Erythrocyte Alteration, Immune/Inflammatory Dysregulation, and Brain Dysfunction

<div>Real-time polymerase chain reaction-based validation of messenger RNA levels for 8 significantly dysregulated genes between CM and UM. Samples from 13 children with cerebral malaria (CM) and 12 with uncomplicated malaria (UM) were analyzed. Relative expression levels were calculated from 2<sup>-<i>ΔΔ</i>Ct</sup> values. Values for children with CM are represented by black squares, and values for children with UM are represented by gray circles. The horizontal lines indicate median values. We used the Mann-Whitney <svg height="8.8423pt" id="M52" style="vertical-align:-0.2064009pt" version="1.1" viewbox="-0.0498162 -8.6359 9.58606 8.8423" width="9.58606pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M715 650H476L470 622C550 619 562 610 562 570C562 536 553 481 535 384L523 321C485 121 408 37 283 37C178 37 99 109 134 297L178 532C193 612 199 616 278 622L284 650H29L23 622C105 616 109 609 94 532L48 291C23 160 51 83 98 40C143 -1 202 -16 260 -16C321 -16 387 3 439 49C509 111 542 204 563 312L577 384C595 479 608 533 619 569C629 603 637 620 709 622L715 650Z"></path></g></svg> test to compare the results for the CM and UM groups.</div>

Mediators of Inflammation

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Figure 3: Understanding Human Cerebral Malaria through a Blood Transcriptomic Signature: Evidences for Erythrocyte Alteration, Immune/Inflammatory Dysregulation, and Brain Dysfunction 

Figure 3 | Understanding Human Cerebral Malaria through a Blood Transcriptomic Signature: Evidences for Erythrocyte Alteration, Immune/Inflammatory Dysregulation, and Brain Dysfunction 