Understanding Human Cerebral Malaria through a Blood Transcriptomic Signature: Evidences for Erythrocyte Alteration, Immune/Inflammatory Dysregulation, and Brain Dysfunction
Table 1
Significant genes differentiating between CM and UM ( and adjusted ).
Probe name
Gene symbol (gene name)
Regulation status
Absolute FC
New key players of cerebral malaria
A_33_P3380462
GPR88 (G protein-coupled receptor 88)
Up
9.1
A_23_P140675
EPB42 (protein 4.2, erythrocytic)
Up
6.1
A_23_P134426
GPNMB (glycoprotein NMB)
Up
6
A_23_P58266
S100P (S100 calcium-binding protein P)
Up
4.6
A_24_P277657
GMPR (guanosine monophosphate Reductase)
Up
4.1
A_33_P3323559
CRYAA (crystallin, alpha-A)
Up
4
A_23_P321935
OSBP2 (oxysterol-binding protein 2)
Up
4
A_33_P3326225
SAMD12 (sterile alpha motif domain-containing protein 12)
Down
3.6
A_32_P133072
SPON1 (spondin 1)
Down
3.5
A_33_P3402615
SLC6A9 (solute carrier family 6, member 9)
Up
3.4
A_23_P72077
IL12RB2 (interleukin 12 receptor beta 2)
Down
3.1
A_23_P392942
MSR1 (macrophage scavenger receptor 1)
Up
2.9
A_23_P102731
SMOX (spermine oxidase)
Up
2.6
A_23_P83931
NET1 (Neuroepithelial cell transforming gene1)
Down
2.1
A_24_P298027
AXIN2 (axis inhibitor 2)
Down
2.1
A_33_P3228322
IL18BP (interleukin 18 binding protein)
Down
2.1
A_33_P3234530
TNFRSF25 (tumor necrosis factor receptor superfamily, member 25)
Down
2
A_23_P126844
2.2
A_23_P3849
TRAP1 (tumor necrosis factor receptor-associated protein 1)
Down
2
Previously involved in malaria
A_33_P3343175
CXCL10 (chemokine, CXC motif, ligand 10)
Down
7.7
A_24_P303091
7.8
A_23_P89431
CCL2 (chemokine, CC motif, ligand 2)
Down
7
A_33_P3416668
VWA1 (Von Willebrand factor A domain-containing protein 1)
Up
6.6
A_21_P0011751
CD177 (CD177 antigen)
Up
5.8
A_24_P63019
IL1R2 (interleukin 1 receptor, type II)
Up
5.2
A_33_P3352382
ARG1 (arginase 1)
Up
4.6
A_33_P3319967
4.5
A_33_P3376321
ANK1 (ankyrin 1)
Up
3.2
A_23_P216108
3.5
A_23_P127288
IL2RA (interleukin 2 receptor, alpha)
Down
3
A_24_P139901
GYPC (glycophorin C)
Up
2.9
A_33_P3214550
CXCR2 (chemokine, CXC motif, receptor 2)
Up
2.6
A_24_P257416
CXCL2 (chemokine, CXC motif, ligand 2)
Up
2.1
A_23_P315364
2.5
Partial list of DEGs included in the RNA signature. Interesting candidate genes identified here as new players of human CM (at the top of the table) or previously involved in malaria (at the bottom of the table). Absolute FC values are shown. The eight genes selected for qPCR validation are indicated by an asterisk ().
