Research Article
Circulating IL-17A Levels in Postmenopausal Women with Primary Hyperparathyroidism
Table 1
Clinical and biochemical parameters in postmenopausal PHPT women and controls.
| | Parameters | nv | PHPT | Controls | |
| | — | 50 | 20 | — | | Anthropometric parameters | | Age (years) | — | 66.5 (58.8-74.0) | 69.0 (57.0-75.0) | 0.465 | | BMI (kg/m2) | — | 25.6 (22.9-28.7) | 25.1 (23.0-28.6) | 0.821 | | Biochemical parameters | | Serum calcium (mg/dl) | 8.4-10.4 | 10.8 (10.4-11.4) | 9.5 (9.2-9.8) | <0.0001 | | Ionized calcium (mmol/l) | 1.15-1.29 | 1.40 (1.31-1.48) | — | — | | Serum phosphate (mg/dl) | 3.5-5.0 | 2.6 (2.2-2.9) | 3.4 (3.2-3.8) | <0.0001 | | Serum PTH (pg/ml) | 10.0-65.0 | 135.5 (93.7-212.8) | 50.0 (38.0-60.0) | <0.0001 | | Alkaline phosphatase (U/l) | 40-120 | 85.0 (65.5-122.5) | 65.0 (57.0-83.0) | 0.003 | | 25OHD (ng/ml) | 30.0-50.0 | 17.8 (9.4-25.1) | 23.7 (17.4-31.8) | 0.005 | | eGFR (ml/min) | >60.0 | 85.0 (65.0-107.5) | 79.2 (62.0-102.5) | 0.453 | | Urine calcium (mg/kg/24 h) | <4.0 | 4.0 (2.2-5.9) | 2.3 (1.6-3.3) | 0.020 | | sRANKL (pmol/l) | — | 105.7 (71.9-163.3) | 155.4 (80.9-244.2) | 0.148 | | OPG (pmol/l) | — | 6.7 (5.9-8.3) | 7.5 (5.7-11.5) | 0.117 | | sRANKL/OPG | — | 14.6 (9.7-27.6) | 17.9 (10.8-33.1) | 0.605 | | IL17 (pg/ml) | — | 13.0 (8.4-23.1) | 11.2 (9.6-22.9) | 0.787 | | Bone densitometric parameters | | Lumbar -score | — | | | 0.028 | | Femur neck -score | — | | | 0.317 | | Total hip -score | — | | | 0.169 |
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PHPT: primary hyperparathyroidism; BMI: body mass index; 25OHD: 25-hydroxyvitamin D; sRANKL: soluble receptor activator of NF-κB ligand; OPG: osteoprotegerin; IL17: interleukin 17.
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