Identification of Potential Biomarkers and Immune Features of Sepsis Using Bioinformatics Analysis

Table 2

(a) Functions enriched for the genes involved in cluster A

Term	Description	Count	value
GO:0050852	T-cell receptor signaling pathway	16
GO:0006955	Immune response	14
GO:0031295	T-cell costimulation	12
GO:0007166	Cell surface receptor signaling pathway	11
GO:0007169	Transmembrane receptor protein tyrosine kinase signaling pathway	8
GO:0050776	Regulation of immune response	8
GO:0042110	T-cell activation	7
GO:0019882	Antigen processing and presentation	7
GO:0042102	Positive regulation of T-cell proliferation	7
GO:0002504	Antigen processing and presentation of peptide or polysaccharide antigen via MHC class II	6
GO:0060333	Interferon-gamma-mediated signaling pathway	6
GO:0019886	Antigen processing and presentation of exogenous peptide antigen via MHC class II	6
GO:0002250	Adaptive immune response	6
GO:0045087	Innate immune response	6	0.00105484
hsa04660	T-cell receptor signaling pathway	11
hsa04514	Cell adhesion molecules (CAMs)	11
hsa04612	Antigen processing and presentation	10
hsa05166	HTLV-1 infection	10
hsa05332	Graft-versus-host disease	9
hsa05330	Allograft rejection	9
hsa04940	Type I diabetes mellitus	9
hsa05320	Autoimmune thyroid disease	9
hsa04640	Hematopoietic cell lineage	9
hsa05416	Viral myocarditis	8
hsa05323	Rheumatoid arthritis	8
hsa05340	Primary immunodeficiency	7
hsa04672	Intestinal immune network for IgA production	7
hsa05321	Inflammatory bowel disease (IBD)	7
hsa04650	Natural killer cell-mediated cytotoxicity	7	0.00000753
hsa05322	Systemic lupus erythematosus	7	0.0000129

(b) Functions enriched for the genes involved in cluster B

Term	Description	Count	value
GO:0045087	Innate immune response	7
GO:0006508	Proteolysis	5	0.004385255
GO:0019731	Antibacterial humoral response	4
GO:0006955	Immune response	4	0.019097644
GO:0001878	Response to yeast	3
GO:0050829	Defense response to Gram-negative bacterium	3	0.002549924
GO:0071347	Cellular response to interleukin-1	3	0.004210679
GO:0022617	Extracellular matrix disassembly	3	0.004809135
GO:0050830	Defense response to Gram-positive bacterium	3	0.005979232
GO:0071356	Cellular response to tumor necrosis factor	3	0.009834724
GO:0071222	Cellular response to lipopolysaccharide	3	0.010355235
GO:0045766	Positive regulation of angiogenesis	3	0.010708943
GO:0042742	Defense response to bacterium	3	0.016637646
GO:0006032	Chitin catabolic process	2	0.009550291
GO:0009635	Response to herbicide	2	0.009550291
GO:0019732	Antifungal humoral response	2	0.01361651
GO:0044130	Negative regulation of growth of symbiont in host	2	0.021701096
GO:0070207	Protein homotrimerization	2	0.029722278
GO:0002227	Innate immune response in mucosa	2	0.033709241
GO:0035987	Endodermal cell differentiation	2	0.036358505
GO:0032715	Negative regulation of interleukin-6 production	2	0.03768053
GO:0050766	Positive regulation of phagocytosis	2	0.03900082
GO:0010043	Response to zinc ion	2	0.048194457