Mibefradil and Flunarizine, Two T-Type Calcium Channel Inhibitors, Protect Mice against Lipopolysaccharide-Induced Acute Lung Injury

Figure 6

Preventive effects of flunarizine on LPS-induced ALI. Flunarizine (30 mg/kg) was treated 30 min before LPS exposure, and mice were sacrificed 6 h after LPS exposure. The total cell counts (a) in BALF, MPO activities (b) in lung tissue, total protein concentration (c) in BALF, extravasation of Evans blue dye (d) in lung tissue, TNF-α (e) and IL-6 (f) levels in BALF, and pathological changes (g) in the lung were measured. All values are (). ^#, compared with vehicle-treated control; , significant compared with LPS alone; , significant compared with LPS alone.

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