Research Article
Methimazole Inhibits the Expression of GFAP and the Migration of Astrocyte in Scratched Wound Model In Vitro
Figure 1
Methimazole inhibited the upregulation of GFAP protein and brevican mRNA expression in scratched astrocytes (12 hours). (a) Methimazole exerted no cell toxic effect on astrocyte viability study. (b) Methimazole inhibited GFAP upregulation in scratched astrocytes. (c) Methimazole inhibited brevican mRNA expression in scratched astrocytes. (d) Methimazole did not inhibit neurocan mRNA expression in scratched astrocytes. (e) Methimazole did not inhibit phosphacan mRNA expression in scratched astrocytes. All values were expressed as , (a) or 5 (b–e). vs. control; # vs. scratch.
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