Overexpression of Ubiquitin-Specific Protease 2 (USP2) in the Heart Suppressed Pressure Overload-Induced Cardiac Remodeling

Figure 2

Overexpression of USP2 improves pressure overload-induced cardiac dysfunction. (a) Representative M-mode echocardiography of the left ventricular chamber and echocardiographic assessment of EF% (b) and FS% (c) from AAV-Control or AAV-USP2-treated mice following sham or TAC. Measurements of LVAWd, LVAWs, LVIDd, LVIDs, LAPWd, and LVPWs are shown in (d–i). and (AAV9-Control plus TAC vs. AAV9-Control plus sham); ^# and ^## (AAV9-Control plus TAC vs. AAV9-USP2 plus TAC). /group.

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