IκB Kinase Inhibitor VII Modulates Sepsis-Induced Excessive Inflammation and Cardiac Dysfunction in 5/6 Nephrectomized Mice

Figure 1

5/6 nephrectomy-induced chronic kidney dysfunction causes augmentation of cardiac dysfunction mediated by LPS administration or CLP. (a–c) 5/6 nephrectomized sham or 5/6 nephrectomized mice were treated with either LPS (2 mg/kg) or vehicle, i.e., PBS intraperitoneally. The cardiac function was evaluated after 18 hours. Data representing percentages of (a) EF, (b) FCA, and (c) FS. The group evaluated were 5/6 nephrectomized sham and vehicle treated (PBS), 5/6 nephrectomized sham and PBS, 5/6 nephrectomized sham and LPS (2 mg/kg), and 5/6 nephrectomized and LPS (2 mg/kg). (d–f) 5/6 nephrectomized sham or 5/6 nephrectomized mice were submitted to CLP or sham surgery. The cardiac function was evaluated after 24 hours. Data representing percentages of (d) EF, (e) FCA, and (f) FS. The groups evaluated were 5/6 nephrectomized sham, 5/6 nephrectomized and sham operated, 5/6 nephrectomized sham and CLP, and 5/6 nephrectomized and CLP. The data are presented as . compared to 5/6 nephrectomized sham group with respective treatments; ^# compared to respective vehicle-treated (PBS) or sham group.

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