Prostanoid Receptor Subtypes and Its Endogenous Ligands with Processing Enzymes within Various Types of Inflammatory Joint Diseases

Figure 2

Detection of microsomal prostaglandin E synthase-1 (mPGES-1) mRNA (a) and the number of mPGES-1-IR cells (b) in patients with joint trauma (JT), osteoarthritis (OA) and rheumatoid arthritis (RA). (a, b) Quantification of mPGES-1 mRNA (a) and immunofluorescence positive cells (b) shows that mPGES-1 expression was more prominent in various forms of inflammatory joint disease compared to synovium of controls; however, in patients with RA and OA, it was significantly higher compared to JT (Data are shown as , , one-way ANOVA followed by Tukey’s test). C: Immunofluorescence microscopy for mPGES (FITC green fluorescence) shows that the number of synovial mPGES-IR cells is increased in various forms of inflammatory joint disease compared to controls which was highest in osteoarthritic synovium. DAPI blue fluorescence shows nuclear staining. . (, compared to control; , compared to JT patients).

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