TLR7 Polymorphism (rs179008 and rs179009) in HIV-Infected Individual Naïve to ART
Table 2
Frequency distribution of genotypes/alleles and risk estimates of TLR7 rs179008, Gln11Leu (A/T) and rs179009, IVS2-151(A/G) polymorphisms in the HIV-infected individuals and healthy controls.
Model
Genotypes TLR7 rs179008, A/T
HIV-infected individuals (%)
Healthy controls (%)
value
OR (95% CI)
Codominant
AA
124 (82.7%)
128 (81.0%)
1
Reference
AT
21 (14.0%)
26 (16.5%)
0.85
0.90 (0.45-1.81)
TT
5 (3.3%)
4 (2.5%)
0.59
1.54 (0.31-7.60)
Allele
TLR7 rs179008 A/T allele
(%)
(%)
value
OR (95% CI)
A
269 (89.66%)
282 (89.24%)
1
Reference
T
31 (10.33%)
34 (10.75%)
0.96
0.96 (0.55-1.65)
Dominant
AA
124 (82.7%)
128 (81%)
1
Reference
AT-TT
26 (17.3%)
30 (19%)
0.94
0.98 (0.52-1.85)
Recessive
AA-AT
145 (96.7%)
154 (97.5%)
1
Reference
TT
5 (3.3%)
4 (2.5%)
0.62
1.42 (0.34-5.92)
Overdominant
AA-TT
129 (86%)
132 (83.5%)
1
Reference
AT
21 (14%)
26 (16.5%)
0.75
0.89 (0.45-1.79)
Model
Genotypes TLR7 rs179009 A/G
HIV patients (%)
Healthy controls (%)
value
OR (95% CI)
Codominant
AA
110 (73.3%)
100 (63.3%)
1
Reference
AG
27 (18.0%)
46 (29.1%)
0.016
0.42 (0.23-0.77)
GG
13 (8.7%)
12 (7.6%)
0.86
0.97 (0.40-2.43)
Allele
Allele TLR7 rs179009 A/G
(%)
(%)
value
OR (95% CI)
A
247 (80.71%)
246 (77.84%)
1
Reference
G
53 (17.32%)
70 (22.15%)
0.19
0.75 (0.50-1.14)
Dominant
AA
110 (73.3%)
100 (63.3%)
1
Reference
AG-GG
40 (26.7%)
58 (36.7%)
0.016
0.52 (0.30-0.89)
Recessive
AA-AG
137 (91.3%)
146 (92.4%)
1
Reference
GG
13 (8.7%)
12 (7.6%)
0.68
1.21 (0.48-3.07)
Overdominant
AA-GG
123 (82%)
112 (70.9%)
1
Reference
AG
27 (18%)
46 (29.1%)
0.003
0.42 (0.23-0.77)
N = number of subjects; % = frequency of genotypes/alleles. The presence of AA for AT, TT for rs179008, AA for AG, GG for rs179009, and A allele for T and A allele for G was taken as a reference group for statistical analysis.
